![]() These processes are tightly regulated and employ a plethora of proteins. ‘The central dogma’ states that genetic sequence information from DNA is transcribed to RNA and subsequently translated into proteins. This study provides a rich resource of human TF interactions and also act as a starting point for future studies aimed at understanding TF-mediated transcription. Moreover, TF interactions with basal transcription machinery are mainly observed through TFIID and SAGA complexes. We also observe 202 TF-TF interactions, of which 118 are interactions with nuclear factor 1 (NFI) family members, indicating uncharacterized cross-talk between NFI signaling and other TF signaling pathways. By performing clustering and correlation analyses, we identify subgroups of TFs associated with specific biological functions, such as RNA splicing or chromatin remodeling. The BioID analysis identifies more high-confidence interactions, highlighting the transient and dynamic nature of many of the TF interactions. Here, we identify 67 protein–protein interactions for 109 different human TFs through proximity-dependent biotinylation (BioID) and affinity purification mass spectrometry (AP-MS), respectively. ![]() Transcription factors (TFs) interact with several other proteins in the process of transcriptional regulation.
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